The use of Local Vitamin D3 Gel in Immediate Dental Implants: A Randomized Controlled Study

Document Type : Review Article

Authors

Department of Oral Medicine, Periodontology, Diagnosis and Dental Radiology, Faculty of Dental Medicine, Al-Azhar University, Assiut, Egypt .

10.21608/aadj.2025.313907.1188

Abstract

 Aim:  This study was performed to evaluate the osteogenic efficacy of vitamin D3 
on immediate dental implant by clinical and radiographic assessments. Subjects and 
methods:  This was a prospective randomized, clinical study including 30 patients 
with decayed hopeless tooth indicated for extraction and seeking implant placement. 
Patients were selected from those attending at the outpatient clinic of Oral Medicine 
and Periodontology Department, Faculty of Dental Medicine, Al-Azhar University 
“Assiut branch” seeking extraction and dental implant placement. The patients were 
divided into two groups: Group (1): 15 patients received immediate dental implant 
placement alone used as control group, and Group (2): 15 patients received extraction 
combined with dental implant placement plus local application of vitamin D3 gel on the 
socket as test group.  Results: There was no statistically significant difference between 
two groups in visual analogue scale (VAS) at day 1, and 14 but there was a statistically 
significant decrease in group 2 at day 3, and 7 compared to group 1. According to 
modified plaque index, there was no statistically significant difference between two 
groups at 3 months and at 6 months. Moreover, the modified plaque index means were 
statistically different across different time periods in group 1 only, but not statistically 
different in group 2. Regarding probing depth, there was no statistically significant 
difference between the two groups at baseline, 3 months and 6 months. However, the 
probing depth means were statistically significant different across different time periods 
when compared in each study group (decreases by time). Conclusion: The current 
study showed that topical application of Vitamin D3 in immediate dental implant 
placement mildly improves osseointegration and may induce anti-inflammatory effect 
in peri-implant status

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Al-Azhar Assiut Dental Journal
Volume 8, Issue 1
April 2025
Pages 109-120

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