Effectiveness of Hydroxyapatite Reinforced Chitosan Hydrogel in Modulation of Osseointegration Around Immediate Dental Implant (Randomized Single Blind Control Study)

Document Type : Original Article

Author

ORAL AND MAXILLOFACIAL SURGERY DEPARTMENT, FACULTY OF DENTISTRY, MINIA UNIVERSITY, EL MINIA, EGYPT

10.21608/aadj.2025.429984

Abstract

 Aim: to evaluate effectiveness of hydroxyapatite reinforced chitosan hydrogel in 
modulation of osseointegration round immediate dental implant in a randomized single 
blind control study. Subjects and methods: parallel arm, single blind randomized 
control clinical trial A total of 20 healthy patients of either gender aged from 20-50 years 
who are seeking extraction and placement of immediate dental implant for mandibular 
teeth. Randomly assigned to either test group IMH were injection of chitosan/ 
hydroxyapatite hydrogel into extraction socket prior to immediate implant placement 
or Control group (IMC) were conventional immediate implant placement was applied. 
Clinical assessment of (postoperative pain, infection and swelling), implant 1ry and 
2ry stability evaluation and radiographic assessment via CBCT at 3 and 6 months 
postoperative. Results: Both groups showed significant increase in implant stability 
from initial placement to 6 months mark where p value <0.001 for both groups, though 
Group IMH showed a more substantial increase in stability values over this period. 
Both groups demonstrated significant increases in bone density across all time intervals 
with p<0.001. Group IMH demonstrated superior outcomes in terms of bone density by 
the 6-month mark. Conclusion: hydroxyapatite reinforced chitosan hydrogel used with 
immediate implants provided less patient discomfort, improved implant stability and 
has positive effect on bone density

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