Evaluation of Xenogeneic Bone Graft and Bone Marrow Mesenchymal Stem Cells Mixture in Promoting Osteogenesis of Jaw Bone Defects (Clinical and Radiographic study)

Document Type : Original Article

Authors

1 Assistant Lecturer of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Faculty of Dentistry, Badr University, Cairo, Egypt.

2 Professor of Oral and Maxillofacial Surgery, Head of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Al-Azhar University – Assiut, Egypt

3 Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Al-Azhar University – Assiut, Egypt boys

4 Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Al-Azhar University, Assuit, Egypt.

Abstract

Aim: The aim of this work was to evaluate bone regeneration capacity of 
Xenogeneic bone graft and Bone marrow mesenchymal stem cells (BMSCs) mixture 
in Osseous Jaw defects. Subjects and Methods: This study was carried out on 10 
patients, aging from 15 to 50 years old, who had osseous defects due to benign tumor 
or large cyst ≥3cm3
 by clinical and radiographic examination. All Defects were 
grafted with a mixture of BMSCs seeded into collagen sponge and xenogeneic bone 
graft. All patients were subjected to a panoramic radiograph, cone-beam computed 
tomography (CBCT) to assess jaw bony defect size, bone volume, and bone density. 
Results: The significance evaluation for volumetric changes for each time interval 
revealed significant difference (P < 0.05) except for immediate postoperative which 
were insignificant different. The significance evaluation for bone density each time 
interval revealed insignificant difference except for bone density change percentage 
which revealed significant difference (P<0.05). Conclusion: The use of autologous 
BMSCs seeded on gelatin scaffold combined with xenogeneic bone graft was promising 
for regenerating bone at odontogenic large defects ≥ 3 cm3
.

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Al-Azhar Assiut Dental Journal
Volume 7, Issue 1
April 2024
Pages 113-122

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