Evaluation of the Efficacy of Ciprofloxacin as Topical Adjunctive Therapy in Non-Surgical Treatment of Stage I and II Grade A Periodontitis (Clinical and Biochemical Study)

Ibrahim, Ibrahim Hammad; Mohamed, Mostafa Mohamed Sameeh; Edrees, Mohamed Fouad

doi:10.21608/aadj.2023.326282

Evaluation of the Efficacy of Ciprofloxacin as Topical Adjunctive Therapy in Non-Surgical Treatment of Stage I and II Grade A Periodontitis (Clinical and Biochemical Study)

Document Type : Original Article

Authors

¹ Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egypt.

² Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egyp.

³ Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egyp

10.21608/aadj.2023.326282

Abstract

Aims: This study was performed to evaluate clinically and biochemically the
efficacy of ciprofloxacin as adjunctive in non-surgical treatment of stage I and II Grade
A periodontitis, through evaluation of the clinical parameters as well as IL-6 level
in GCF.. Subjects and Methods: 20 patients of both sex divided into two groups.
Group 1 included 10 patients were treated by only conventional periodontal therapy
(scaling and root planing). Group 2 included 10 patients were treated by scaling and
root planing followed by topical intra pocket application of Ciprofloxacin gel 1%.
Evaluated clinically at baseline, 1 month and 3 months. The biochemical evaluation
of interleukin 6 was done at baseline, 1 month and 3 months. Results: Clinical
parameter showed a statistically significant differences in both groups at the different
intervals when compared to the baseline. All parameter showed in group 2 statistically
significant difference between 1 month and 3 month. When groups 2 was compared
to group 1 all parameter showed statistically reduction at 1 month and 3 months in
relation to baseline. Biochemical marker showed a statistically significant differences
were showed in both groups at the different intervals when compared to the baseline
with statistically significant difference between 1 month and 3 month. Conclusion: The
topically applied ciprofloxacin seamed to exhibit a synergistic action in treatment of
stage I and II grade A periodontitis

Keywords