The Impact of Topically Applied 1% Phenytoin Gel on Treatment of Periodontitis Stage II and III Grade A

Salatein, Alaa El-Dein Mohamed; Edrees, Mohamed Fouad; Zayed, Gamal Mohamed Soltan; Ibrahim, Ibrahim Hammad; Bakry, Ahmed Mohamed

doi:10.21608/aadj.2023.296418

The Impact of Topically Applied 1% Phenytoin Gel on Treatment of Periodontitis Stage II and III Grade A

Document Type : Original Article

Authors

¹ Department of Oral medicine, Periodontology, Diagnosis and Oral radiology, Faculty of Dental Medicine, (Assiut, boys), Al-Azhar University, Egypt.

² Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy (Assiut, girls), Al-Azhar University, Egypt

³ Department of Oral and Maxillofacial Radiology, Faculty of dentistry, Minia University, Egypt

10.21608/aadj.2023.296418

Abstract

Aim: The aim of the present study was to evaluate the efficacy of topically applied
1% phenytoin as an adjunctive treatment in Stage II or III, Grade A periodontitis
patients. Subjects and Methods: This study was designed as a split-mouth randomized
controlled clinical, carried out on 20 patients of both sexes (12 female and 8 male),
aged from (33-55) years with mean age (43.25± 6.64) with stage II or III, grade A
periodontitis. Patients’ sides were classified randomly into the following groups: Group < /div>
I: included 20 sides with Stage II or III, Grade A periodontitis patients treated by
scaling and root planing alone. Group II: included 20 sides with Stage II or III, Grade A
periodontitis patients treated by scaling and root planing combined with 1% phenytoin
gel. All patients were evaluated clinically at; baseline, 1, 3 and 6 months using plaque
index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment
level (CAL) and radiographically by evaluation of the marginal bone level (MBL).
Results: Phenytoin group: showed reduction in PPD and CAL, as well as significant
gain in MBL than group I at 6 months after treatment Conclusion: The adjunctive
use of 1% PHT in-situ gel exhibited an attractive effect on probing pocket depth
reduction clinical attachment gain in non-surgical treatment of stage II and III grade A
periodontitis. Phenytoin 1% in-situ gel seemed to have an osteogenic efficacy through
the reported marginal bone gain in treatment of stage II and III grade A periodontitis
patients.

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