Evaluation of the Efficacy of 1%Alendronate Gel as Adjunctive Treatment in Class II Furcation Defects (Clinical, Radiographic and Biochemical Study)

Shehab, Dalia Hamed; Edrees, Mohamed Fouad; Gaber, Ahmed Hussien

doi:10.21608/aadj.2021.44852.1051

Evaluation of the Efficacy of 1%Alendronate Gel as Adjunctive Treatment in Class II Furcation Defects (Clinical, Radiographic and Biochemical Study)

Document Type : Original Article

Authors

¹ Periodontology , oral medicine,oral radiology and diagnosis , Faculty of dentistry ,azhar university (Assiut branch) , Assiut

² Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology Department, Faculty of Dentistry, Al-Azhar University (Assiut Branch)

³ Oral Pathology, Faculty of Dentistry, Al-Azhar University (Assiut Branch)

10.21608/aadj.2021.44852.1051

Abstract

Aim: This study was designed to evaluate the efficacy of 1% alendronate gel as an adjunctive therapy to scaling and root planing in the treatment of class II furcation defects. Patients and method: Twenty-six patients with mandibular class II furcation involvement were selected from the out-patient clinic, Oral Medicine and Periodontology Department, Faculty of Dentistry, Al-Azhar University, Assiut Branch. They were divided into two equal groups. Group I received conventional periodontal therapy alone, while group II received conventional periodontal therapy combined with intra-furcal application of 1% alendronate gel as adjunctive therapy. All patients were evaluated clinically, radiographically as well as for RANKL level in GCF at base line, 3 and 6 months. Results: Both groups showed a high significant difference between base line and 6 months in all clinical parameters (PI, GI, VPD, CAL and HPD), radiographic parameters (bone density) and RANKL level in GCF. There was a statistical significant difference to group II when compared to group I in VPD and HPD at 6 months only and in CAL, bone density and RANKL level at 3 and 6 months. Conclusion: intra-furcal application of 1%Alendronate gel seemed an attractive effect as adjunctive therapy in improving the clinical, radiographic parameters and RANKL level in GCF in the treatment of class II furcation defects.

Keywords

Main Subjects